BackgroundPreprint usage is growing rapidly in the life sciences; however, questions remain on the relative quality of preprints when compared to published articles. An objective dimension of quality that is readily measurable is completeness of reporting, as transparency can improve the reader’s ability to independently interpret data and reproduce findings.MethodsIn this observational study, we initially compared independent samples of articles published in bioRxiv and in PubMed-indexed journals in 2016 using a quality of reporting questionnaire. After that, we performed paired comparisons (...) between preprints from bioRxiv to their own peer-reviewed versions in journals.ResultsPeer-reviewed articles had, on average, higher quality of reporting than preprints, although the difference was small, with absolute differences of 5.0% [95% CI 1.4, 8.6] and 4.7% [95% CI 2.4, 7.0] of reported items in the independent samples and paired sample comparison, respectively. There were larger differences favoring peer-reviewed articles in subjective ratings of how clearly titles and abstracts presented the main findings and how easy it was to locate relevant reporting information. Changes in reporting from preprints to peer-reviewed versions did not correlate with the impact factor of the publication venue or with the time lag from bioRxiv to journal publication.ConclusionsOur results suggest that, on average, publication in a peer-reviewed journal is associated with improvement in quality of reporting. They also show that quality of reporting in preprints in the life sciences is within a similar range as that of peer-reviewed articles, albeit slightly lower on average, supporting the idea that preprints should be considered valid scientific contributions. (shrink)

ArgumentThis article studies the roles three science-based models play in Dutch policy and decision making processes. Key is the interaction between model construction and environment. Their political and scientific environments form contexts that shape the roles of models in policy decision making. Attention is paid to three aspects of the wider context of the models: a) the history of the construction process; b) the political and scientific environments; and c) the use in policy processes over longer periods of time. Models (...) are more successfully used when they are constructed in astablepolitical and scientific environment. Stability and certainty within a scientific field seems to be a key predictor for the usefulness of models for policy making. The economic model is more disputed than the ecology-based model and the model that has its theoretical foundation in physics and chemistry. The roles models play in policy processes are too complex to be considered as straightforward technocratic powers. (shrink)

This article addresses the role of science and science advisory bodies in modeling practices for the support of policy-making procedures in the Netherlands in the field of health care. The authors show, based on a detailed investigation of a prestigious interdisciplinary modeling project in which an economic care model was developed for governmental use, that science advisory bodies are entangled with the policy actors they advise in what we call boundary configurations. Boundary configurations are strongly situated interconnections between science advisory (...) institutes and policy institutions that share a specific approach to problem definitions and methods and that are embedded in specific social, discursive, and material elements. Importantly, as the case study shows, such boundary configurations shape the kind of science, and related, the kind of social and political theories about the world, that is effectuated in modeling practices. In this case study, the boundary configuration in which economic experts and policy makers participated contributed to the articulation of health care in terms of a market-based policy program for the health care sector. (shrink)

The main objective of the Flemish research project ‘Nanotechnologies for tomorrow’s society’ (NanoSoc) is to develop and try out an interactive process as a suitable methodology for rendering nanoresearchers aware of underlying assumptions that guide nanotech research and integrating social considerations into the research choices they face. In particular, the NanoSoc process should sustain scientists’ capacities to address growing uncertainties on the strategic, scientific and public acceptance level. The article elaborates on these uncertainties and involved dilemmas scientists are facing and (...) proposes a process approach which addresses strategic uncertainty by alternating between ‘visioning’ and ‘technology assessment’; a process design which manages complexity by promoting reflexivity among scientists by exposing them to deliberations in civil society (social experts, stakeholders, citizens) on plausible futures with nanotechnologies; and as an answer to societal ambivalence, certain process quality requirements such as an attitude of perplexity or openness towards ‘plurality’ and an attitude of ‘temporary closure’, both in support of understanding and learning from differences. (shrink)

A thirteenth-century manuscript attributes a short fragment of a speech Pros Basilea to the fourth-century orator Themistius. Its editors argue that the piece is authentic and was addressed to Theodosius I. In fact, style and vocabulary, geographical references, and the way the divinity of the emperor is highlighted, strongly argue against its authenticity. The fragment must be dated much later than the fourth century: this article suggests a date in the reign of Justinian.

Paideia– i.e. Greek culture, comprising, amongst other things, language, literature, philosophy and medicine – was a constituent component of the social identity of the elite of the Roman empire: as a number of influential studies on the Second Sophistic have recently shown, leading members of society presented themselves as such by their possession and deployment of cultural capital, for example by performing oratory, writing philosophy or showcasing medical interventions. As the ‘common language’ of the men ruling the various parts of (...) the empire, Greek culture became a characteristic of, and thus ade factocondition for, leading socio-political positions. Whilst most elite men would have taken for granted a good cultural education no less than a leading position, an outstanding command of the classical Greek language, literature and tradition as displayed in epideictic performances allowed some orators, philosophers and doctors to move distinctively up the social ladder, sometimes reaching the ears of, and thereby wielding influence over, the emperor himself. (shrink)

In the first phase of the research project Nanotechnologies for Tomorrow's Society (www.nanosoc.be), the research consortium explored a variety of futuristic visions or technoscientific imaginaries. This exploration took the form of a Policy Delphi, adapted to the particular objective of jointly constructing nano-imaginaries, taking participants' personal visions of possible future applications and societal issues as a starting point. The participants were nanoresearchers, as well as societal experts and primary involved citizens. In this article, the authors describe the theoretical frame that (...) inspired their methodological approach, present the analytical results obtained, and bring some reflections to the fore that arose as a result of the performance and analysis of this Delphi-exercise. (shrink)

This book, which transcends the boundaries between literature, social history, and philosophy, studies Plutarch's practical ethics, a group of twenty-odd texts ...

Background A team-based approach has been advocated for advance care planning in nursing homes. While nurses are often put forward to take the lead, it is not clear to what extent other professions could be involved as well. Objectives To examine to what extent engagement in advance care planning practices, knowledge and self-efficacy differ between nurses, care assistants and allied care staff in nursing homes. Design Survey study. Participants/setting The study involved a purposive sample of 14 nursing homes in Flanders, (...) Belgium. Nurses, care assistants and allied care staff completed a survey. Ethical considerations The study was approved by the University Hospital of Brussels, as part of a cluster randomized controlled trial. Results One hundred ninety-six nurses, 319 care assistants and 169 allied staff participated. After adjusting for confounders, nurses were significantly more likely than care assistants to have carried out advance care planning conversations and documented advance care planning ; differences not found between allied staff and care assistants. Advance care planning knowledge total scores differed significantly, with nurses ; 95% confidence interval 0.08–0.17; p < 0.001) and allied staff scoring higher than care assistants. We found no significant differences regarding self-efficacy. Discussion While nursing home nurses conducted more advance care planning conversations and documentation than allied care staff and care assistants, these two professional groups may be a valuable support to nurses in conducting advance care planning, if provided with additional training. Conclusions Allied care staff and care assistants, if trained appropriately, can be involved more strongly in advance care planning to enhance relational and individual autonomy of nursing home residents, alongside nurses. Future research to improve and implement advance care planning should consider this finding at the intervention development stage. (shrink)

We have sought to expound how Jan van Ruusbroec goes about representing the relationship of love between God and human beings by proceeding from God’s inner life of love. Therefore, in the first part of our paper we elucidated Ruusbroec’s view of the inner love reality of the Triune God. In the second part we explained how genuine Christian mystical life is founded within the intra-trinitarian life of love. Prior to discussing the characteristics of Ruusbroec’s trinitarian position, we dwelled upon (...) the author’s development of his idea of the Trinity from a personal perception of his relation with God, the embedding of Ruusbroec’s love-mysticism in traditional Christian faith and his repeated clarification of the Triune God from two perspectives: God’s nature and God’s essence. We found that, in his explanation of God’s nature, Ruusbroec underlines its fruitfulness as a way of demonstrating that God is one dynamic of love, without beginning or end, which ceaselessly and simultaneously consists in “flowing out” and “being flowed back”. This phenomenon, we stated, he associates with the concept, “oneness in threeness” and “threeness in oneness”. Through an exposition on the differing features of unity and the Persons of the Trinity, we came to the conclusion that the author in all of his works combines both the origin of “flowing out” and “flowing-back” with the Holy Spirit as the bond or unity of love of Father and Son. From this we concluded that none of the Persons is the principle or source of regiratio, i.e. return, to the unity. The view that God’s unity of Persons is the principle of exitus-reditus – and not only the third Person as recent scientific research has sought to demonstrate – is what we consider to be the heart of Ruusbroec’s trinitarian way of thinking. We ascertained, further, that the author not only links the unity of the Persons with fruitfulness; he believes that the same “fruitful” unity, drawing in the divine Persons on the level of God’s nature, is the “enjoying” unity on the level of God’s essence. By means of the distinction between God’s enjoying unity and the unity of God’s fruitful nature, Ruusbroec explicates the true facts of the intra-trinitarian life of love. The perception leads him to conclude that God, as a unity of Persons, is ceaselessly and simultaneously working and enjoying. In the second part, we illustrated how Ruusbroec’s trinitarian thought mirrors the basis of his mystical doctrine: the conviction that mystics are unified with the divine Persons both in working and enjoying, and that they are one reality of love with God. We explained how the author, first of all, maintains that mystics, who bear a full likeness to God’s fruitful nature, ceaselessly turn to good works and virtues, just as God, ceaselessly, through the divine Persons, flows out in love. We then avered that the likeness to God’s nature is not the result of human effort and that it arises from God’s touch within the human mind. Moreover, we showed that Ruusbroec, in accordance with his intuition that God’s fruitful unity is both out-flowing and inwarddrawing, believes that God is both impelling humans outward toward virtues and drawing them into God’s unity of love. In analogy with the first part of our argument – as far as the “return” of humans is concerned – we ascertained that our author is stressing the initiative of God’s unity of the Holy Spirit, i.e. the mutual love between the Father and the Son. We found the emphasis on God’s inward-drawing unity to be of great significance, because God’s unity of love also plays a crucial role with respect to the transition to “enjoyment” of human beings in God’s essence. We clarified how human beings, according to Ruusbroec, through the likeness to God’s nature, participate in the enjoyment of God’s essence with the divine Persons. We pointed out that the union in God’s essence is the most intimate experience, but not the end-point of the mystical life as, according to our author, contemplatives are directed, again and again, to good works. Lastly, we arrived at the conclusion that Ruusbroec considers the mystical life, like the life of God, to be ceaselessly consisting of action and enjoyment. However, it is not primarily the analogy with God’s trinitarian reality of love that Ruusbroecs stresses. Basically, he accentuates the fact that mystics ceaselessly experience unification with the divine Persons, both in working and enjoying. This means that mystics, united with the divine Persons in one enjoyment on the level of God’s essence, concurrently experience that, with the divine Persons, they also “share” in God’s “flowing” and “ebbing” on the level of God’s nature. On the basis of this we have affirmed that, according to Ruusbroec, God’s activity and enjoyment in the “Divinity Itself” is God’s activity and enjoyment in the human being, and the inverse. Moreover, we have shown how the author considers both moments to occur simultaneously, both in God and in human beings, meaning that the mystical life is continuously one reality of love with God. (shrink)

BackgroundHealthcare professionals and surrogate decision-makers often face the difficult decision of whether to initiate or withhold antibiotics from people with dementia who have developed a life-threatening infection after losing decisional capacity.MethodsWe conducted a vignette-based survey among 1050 Quebec stakeholders (senior citizens, family caregivers, nurses and physicians; response rate 49.4%) to (1) assess their attitudes toward withholding antibiotics from people with dementia lacking decisional capacity; (2) compare attitudes between dementia stages and stakeholder groups; and (3) investigate other correlates of attitudes, including (...) support for continuous deep sedation (CDS) and medical assistance in dying (MAID). The vignettes feature a woman moving along the dementia trajectory, who has refused in writing all life-prolonging interventions and explicitly requested that a doctor end her life when she no longer recognizes her loved ones. Two stages were considered after she had lost capacity: the advanced stage, where she likely has several more years to live, and the terminal stage, where she is close to death.ResultsSupport for withholding antibiotics ranged from 75% among seniors and caregivers at the advanced stage, to 98% among physicians at the terminal stage. Using the generalized estimating equation approach, we found stakeholder group, religiosity, and support for CDS and MAID, to be associated with attitudes toward antibiotics.ConclusionsFindings underscore the importance for healthcare professionals of discussing underlying values and treatment goals with people at an early stage of dementia and their relatives, to help them anticipate future care decisions and better prepare surrogates for their role. Findings also have implications for the scope of MAID laws, in particular in Canada where the extension of MAID to persons lacking decisional capacity is currently being considered. (shrink)

Theory and Practice of Knowledge Transfer: Studies in School Education in the Ancient Near East and Beyond. Edited by W. S. van Egmond and W. H. van Soldt. Publications de l’Institut histo- rique-archéologique néerlandais de Stamboul, vol. 121. Leiden: Nederlands Instituut voor het NabiJe Oosten, 2012. Pp. 111 + 152. €36.04.

Blackshaw and Hendricks have recently developed and defended the impairment argument against abortion, arguing that the immorality of giving a child fetal alcohol syndrome (FAS) provides us with reason to believe that abortion is immoral. In this paper, we forward two criticisms of the impairment argument. First, we highlight that, as it currently stands, the argument is very weak and accomplishes very little. Second, we argue that Blackshaw and Hendricks are fundamentally mistaken about what makes giving a child FAS immoral. (...) Once we acknowledge this, it is clear that our intuitions about giving a child FAS provide no support for the supposed immorality of abortion. (shrink)

Metaphysicians speak of laws of nature in terms of necessity and universality; scientists, in terms of symmetry and invariance. In this book van Fraassen argues that no metaphysical account of laws can succeed. He analyzes and rejects the arguments that there are laws of nature, or that we must believe there are, and argues that we should disregard the idea of law as an adequate clue to science. After exploring what this means for general epistemology, the author develops the empiricist (...) view of science as a construction of models to represent the phenomena. (shrink)

Despite the robust evidence that congruent background music in the physical store environment positively affects consumer reactions, less is known about its effects in an online context. The present study aims to examine whether congruency via multiple elicited crossmodal correspondences between background music and the online store environment leads to more positive affective, evaluative, and behavioral consumer reactions and to investigate the moderating role of shopping goals on this crossmodal congruency effect. Previous research showed that low task-relevant atmospheric cues like (...) music can have a negative effect on consumers when they visit a website with a purchase goal in mind. An online experiment was conducted with 239 respondents randomly assigned to a shopping goal and a music condition. Our results show that crossmodally incongruent background music leads to more positive consumer reactions for experiential browsers and more negative consumer reactions for goal-directed searchers. Conversely, crossmodally congruent background music has a positive effect on experiential browsers and no adverse effect on goal-directed searchers. Additionally, the presence of crossmodally congruent background music leads to more positive consumer reactions than the presence of crossmodally incongruent background music, independent of the shopping goal. We extend previous research on multisensory congruency effects by showing the added value of establishing congruency between music and the store environment via multiple elicited crossmodal correspondences in the online environment, countering previously found negative effects of low-task relevant atmospheric cues for goal-directed searchers. (shrink)

What is empiricism and what could it be? Bas . van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and secondly in a focus on experience that requires a voluntarist view of belief and opinion. Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)

This article discusses experimentation in the context of sixteenth-century natural history, or natural science as I prefer to call it here. It uses predominantly textual sources, many of them manuscript letters, from different European countries, mainly Italy, the Low Countries, France and Germany-Austria. The focus is on the practice of experimentation and its documentation, partly because I proceed from the assumption that the investigation of living nature did not necessarily entail the same type of experimentation as contempo­rary alchemy, pharmacy, or (...) medicine, although all these domains of knowledge and their practitioners overlapped. The subject matter to some extent imposed its own rules. The first part of this essay analyses experimentation in the garden, which often combined practical purposes with research ones. The second and third parts discuss experimentation with both plants and animals that originated in more general questions or led to more wide-ranging conclusions about natural phenomena. The final section discusses the links with natural philosophy in these different types of experimentation in natural science, and addresses the possible implications for the concept of experimentation itself in the period shortly before the ”new science” of the seventeenth century. (shrink)

What is empiricism and what could it be? Bas C. van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and second in a focus on experience that requires a voluntarist view of belief and opinion._ _Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)

This essay argues that there are theoretical benefits to keeping distinct—more pervasively than the literature has done so far—the psychological states of imagining that p versus believing that in-the-story p, when it comes to cognition of fiction and other forms of narrative. Positing both in the minds of a story’s audience helps explain the full range of reactions characteristic of story consumption. This distinction also has interesting conceptual and explanatory dimensions that haven’t been carefully observed, and the two mental state (...) types make distinct contributions to generating emotional responses to stories. Finally, the differences between the mental states illuminate how a given story can be both shared with others and at the same time experienced as personal. (shrink)

“Brave the Shave”, a campaign by the UK charity Macmillan Cancer Support, encourages people to seek sponsorship to shave off all their hair and share the event on social media. Brave the Shave has...

Ending the influence which politicalparties exercised over judicial appointmentswas a prominent aim of the project of reformingthe Belgian criminal justice system in the1990s. However, focusing on various highprofile scandals affecting public confidence inthe judiciary, this paper questions whether thepolitical nature of the judiciary is capable ofbeing eradicated. Drawing on the work ofChantal Mouffe, this analysis starts with aconsideration of the discursive element inpolitical identity, which is furthercorroborated by the semiotics of Saussure andGreimas. Applying this perspective to theBelgian situation in the (...) 1990s, it is arguedthat a redefinition of politics in terms of an``us/them'' divide between citizens andinstitutions took place. In this process,judges were targeted as part of theestablishment and cast as the constitutiveoutside buttressing the collectiveidentification between the media, victims ofcrime and the general public. In explaining theinstitutional gap, individual traits of judgesconstituted a significant focus, as can beshown through the extraordinary visibility ofone judge who courted media attention when hewas tried for sadomasochistic activities in1997. (shrink)

The fundamental texts of the great classical period in modern logic, some of them never before available in English translation, are here gathered together for ...

Organizations such as the EU High-Level Expert Group on AI and the IEEE have recently formulated ethical principles and (moral) values that should be adhered to in the design and deployment of artificial intelligence (AI). These include respect for autonomy, non-maleficence, fairness, transparency, explainability, and accountability. But how can we ensure and verify that an AI system actually respects these values? To help answer this question, I propose an account for determining when an AI system can be said to embody (...) certain values. This account understands embodied values as the result of design activities intended to embed those values in such systems. AI systems are here understood as a special kind of sociotechnical system that, like traditional sociotechnical systems, are composed of technical artifacts, human agents, and institutions but—in addition—contain artificial agents and certain technical norms that regulate interactions between artificial agents and other elements of the system. The specific challenges and opportunities of embedding values in AI systems are discussed, and some lessons for better embedding values in AI systems are drawn. (shrink)

ABSTRACTIn The Netherlands, the public funding of a number of health care services is controversial. What can we learn from this about the moral concerns that underlie these judgements? And, if there is anything to learn, can we use this improved understanding to scrutinise the adequacy of particular decisions concerning the public funding of health care services? In the present paper, I will analyse three cases: corrective surgey, In Vitro Fertilisation and liver transplantation. I will summarise the arguments that have (...) been used to support or to challenge the public funding of these services. I will then assess the merits of Daniels’fair equality of opportunity account of justice in health care. Can this account improve our understanding of the moral concerns underlying our judgements about the public funding of these services? Can it serve to scrutinise the adequacy of particular decisions that are made concerning the public funding of health care services? My answer to both questions will be a qualified yes. Daniels’account can provide guidance, but not because we can deductively infer from it what is right and what is wrong. Instead, I will argue for a more casuistic use of the concept of fair equality of opportunity. (shrink)